Study the therapeutic effect of truffles on Rhodotorula spp. in vivo

Abstract

The current research spots the light on the antimicrobial activity of Terfezia claveryi which was evaluated in vivo. The laboratory animals were divided to four sets, each set contains (10) mice. The sets were as follows:  First set of mice had (two ml/kg) / body wt. of normal saline as a control. As for the second set, they had (two ml/kg) / body wt. of fungal broth (Rhodotorula spp), third set had (two ml/kg) / body wt. of aqueous extract of T. claveryi. While the fourth set had (two ml/kg) / body wt. of fungal broth and also treated with (two ml/kg) / body wt. of aqueous extract of T. claveryi, daily for two weeks orally using gavage tube. The therapeutic effect of aqueous extract of T. claveryi was tested by measuring the serum level for AST, ALT, and ALP. Also, histopathological sections for liver and kidney were examined. The findings of the activity of liver enzymes showed that the statistical analysis of the ALP serum level displayed a substantial increment at the level of probability (p<0.05) in this parameter in the collection of fungal broth treated (71.40±6.25) IU / ml and serum GOT (231.00±9.42) IU / ml compared to the other three sets. Additionally, non-significant differences at the level of probability (P>0.05) in serum GPT level across all four experimental sets were recognized. As for Renal function tests results displayed a substantial increment at the level of probability (P<0.05) of B. urea in fungal broth treated set (28.51±3.10) mg/dl when compared with other three sets. In conclusion, the aqueous extract of T. claveryi was found to have an antimicrobial effect versus the infectious Rhodotorula spp.