Role of hemodialysis and hepatitis C virus infection in circulating Th1 and Th2 cytokines in patients with chronic renal disease
DOI:
https://doi.org/10.63799/Keywords:
HCV,, Hemodialysis,, INF-γ,, TNF-α,, IL-10.Abstract
The present study was performed to evaluate the possible role of Th-1cytokine (IFN-γ, TNF-α) and Th-
2cytokine (IL-10) in immunopathogenesis of hepatitis C in hemodialysis patients. The sandwich ELISA
assay was performed for the detecting the serum levels of these cytokines in 23 hemodialysis HCV
positive (HD/HCV+) patients, 20 HD hemodialysis HCV negative (HD/HCV-) patients in comparison with
apparently healthy control and non-uremic chronic HCV infected patients. Where, the HCV-positive
hemodialysis patients had a blunted TNF-α response (P<0.01) and failed to increase the stimulated IFN-γ
(P<0.01) compared with chronic HCV infected patients without renal disease. On the contrary, IL-10
stimulation was higher in HCV-positive hemodialysis patients (P<0.01). The results showed that the
disturbed cytokine response appeared to focus in the Th1 because the stimulation of Th2 cytokines (IL-10)
was not impaired.
