The effect of meropenem on the liver of albino mice

Abstract

Meropenem is a carbapenem antibiotic with broad-spectrum activity against many pathogens associated with complicated intra-abdominal infection (cIAI), complicated skin and skin structure infection (cSSSI) and bacterial meningitis as well as nosocomial pneumonia. The present study looked at the effect of meropenem on liver tissue in mice, taking into account dose and duration of exposure. Nine matured male albino mice were divided into two groups. Group one ( G1): served as a control group, receiving 0.1 normal saline intravenously every day. Group two (G2): received 0.1 of 100 mg/kg/day meropenem intravenously for 14 days. Animals were weighed before and after treatment, and they were sacrificed by cervical dislocation following either inhalation. After the end of treatment, liver samples were collected, weighted, and processed for histological examination. The findings revealed liver injuries that involved  hepatocytes necrosis, degeneration, blood vessels congestion ,increased the number of cells with divided nuclei, expansion of sinusoid space, pyknotic nuclei, atrophy of nuclei and cytoplasmic vacuolation, aggregation of erythrocytes_. We conclude that meropenem have a negative impact on liver function.